Within the qGenEx services, the directed exome panels allow to restrict the study to a specific group of genes according to each specialty.
qGenEx IMD, analyzes 46 genes associated with ron Metabolism Disorders using complete exome sequencing by NGS.
Use the search engine to find the group of genes included in the panel related to the pathology you are interested in:
Gene | Median coverage | % covered > 10x | % covered > 20x | Associated Phenotype | OMIM disease ID |
---|---|---|---|---|---|
ADAMTSL4 | 96.9 | 0.99 | 0.97 | Ectopia lentis et pupillae, | 225200 |
ADAMTSL4 | 96.9 | 0.99 | 0.97 | Ectopia lentis, isolated, autosomal recessive, | 225100 |
ALX1 | 171.3 | 0.99 | 0.96 | ?Frontonasal dysplasia 3 | 613456 |
ALX3 | 125.6 | 0.78 | 0.71 | Frontonasal dysplasia 1 | 136760 |
ALX4 | 132.6 | 0.96 | 0.89 | Frontonasal dysplasia 2 | 613451 |
ALX4 | 132.6 | 0.96 | 0.89 | Parietal foramina 2 | 609597 |
ALX4 | 132.6 | 0.96 | 0.89 | {Craniosynostosis 5 susceptibility to}, | 615529 |
AMELX | 95.2 | 0.99 | 0.96 | Amelogenesis imperfecta, type 1E, | 301200 |
ANKRD11 | 107.9 | 0.97 | 0.93 | KBG syndrome, | 148050 |
AXIN2 | 133.3 | 1 | 0.99 | Colorectal cancer, somatic, | 114500 |
AXIN2 | 133.3 | 1 | 0.99 | Oligodontia-colorectal cancer syndrome, | 608615 |
BCOR | 131.4 | 0.99 | 0.97 | Microphthalmia, syndromic 2 | 300166 |
BMP4 | 154.5 | 1 | 0.99 | Microphthalmia, syndromic 6 | 607932 |
BMP4 | 154.5 | 1 | 0.99 | Orofacial cleft 11 | 600625 |
C4orf26 | 226.3 | 1 | 1 | Amelogenesis imperfecta, type IIA4, | 614832 |
CDC45 | 184.7 | 0.99 | 0.97 | Meier-Gorlin syndrome 7 | 617063 |
CDON | 156.1 | 0.99 | 0.99 | Holoprosencephaly 11 | 614226 |
CDSN | 25.5 | 0.63 | 0.46 | Hypotrichosis 2 | 146520 |
CDSN | 25.5 | 0.63 | 0.46 | Peeling skin syndrome 1 | 270300 |
CHD7 | 161 | 0.99 | 0.98 | CHARGE syndrome, | 214800 |
CHD7 | 161 | 0.99 | 0.98 | Hypogonadotropic hypogonadism 5 with or without anosmia, | 612370 |
COL11A1 | 98.5 | 0.94 | 0.88 | Fibrochondrogenesis 1 | 228520 |
COL11A1 | 98.5 | 0.94 | 0.88 | Marshall syndrome, | 154780 |
COL11A1 | 98.5 | 0.94 | 0.88 | Stickler syndrome, type II, | 604841 |
COL11A1 | 98.5 | 0.94 | 0.88 | {Lumbar disc herniation, susceptibility to}, | 603932 |
COL11A2 | 14.1 | 0.57 | 0.23 | Deafness, autosomal dominant 13 | 601868 |
COL11A2 | 14.1 | 0.57 | 0.23 | Deafness, autosomal recessive 53 | 609706 |
COL11A2 | 14.1 | 0.57 | 0.23 | Fibrochondrogenesis 2 | 614524 |
COL11A2 | 14.1 | 0.57 | 0.23 | Otospondylomegaepiphyseal dysplasia, | 215150 |
COL11A2 | 14.1 | 0.57 | 0.23 | Stickler syndrome, type III, | 184840 |
COL11A2 | 14.1 | 0.57 | 0.23 | Weissenbacher-Zweymuller syndrome, | 277610 |
COL2A1 | 115.2 | 0.99 | 0.98 | Achondrogenesis, type II or hypochondrogenesis, | 200610 |
COL2A1 | 115.2 | 0.99 | 0.98 | Avascular necrosis of the femoral head, | 608805 |
COL2A1 | 115.2 | 0.99 | 0.98 | Czech dysplasia, | 609162 |
COL2A1 | 115.2 | 0.99 | 0.98 | Epiphyseal dysplasia, multiple, with myopia and deafness, | 132450 |
COL2A1 | 115.2 | 0.99 | 0.98 | Kniest dysplasia, | 156550 |
COL2A1 | 115.2 | 0.99 | 0.98 | Legg-Calve-Perthes disease, | 150600 |
COL2A1 | 115.2 | 0.99 | 0.98 | Osteoarthritis with mild chondrodysplasia, | 604864 |
COL2A1 | 115.2 | 0.99 | 0.98 | Otospondylomegaepiphyseal dysplasia, | 215150 |
COL2A1 | 115.2 | 0.99 | 0.98 | Platyspondylic skeletal dysplasia, Torrance type, | 151210 |
COL2A1 | 115.2 | 0.99 | 0.98 | SED congenita, | 183900 |
COL2A1 | 115.2 | 0.99 | 0.98 | SMED Strudwick type, | 184250 |
COL2A1 | 115.2 | 0.99 | 0.98 | Spondyloepiphyseal dysplasia, Stanescu type, | 616583 |
COL2A1 | 115.2 | 0.99 | 0.98 | Spondyloperipheral dysplasia, | 271700 |
COL2A1 | 115.2 | 0.99 | 0.98 | Stickler sydrome, type I, nonsyndromic ocular, | 609508 |
COL2A1 | 115.2 | 0.99 | 0.98 | Stickler syndrome, type I, | 108300 |
COL2A1 | 115.2 | 0.99 | 0.98 | Vitreoretinopathy with phalangeal epiphyseal dysplasia | 108300 |
COL9A1 | 128.2 | 0.99 | 0.95 | Stickler syndrome, type IV, | 614134 |
COL9A1 | 128.2 | 0.99 | 0.95 | /?Epiphyseal dysplasia, multiple, 6 | 614135 |
COL9A2 | 69.7 | 0.98 | 0.91 | Epiphyseal dysplasia, multiple, 2 | 600204 |
COL9A2 | 69.7 | 0.98 | 0.91 | ?Stickler syndrome, type V, | 614284 |
COL9A2 | 69.7 | 0.98 | 0.91 | {Intervertebral disc disease, susceptibility to}, | 603932 |
COL9A3 | 73.8 | 0.96 | 0.88 | Epiphyseal dysplasia, multiple, 3 with or without myopathy, | 600969 |
COL9A3 | 73.8 | 0.96 | 0.88 | {Intervertebral disc disease, susceptibility to}, | 603932 |
CTSK | 117.2 | 1 | 0.99 | Pycnodysostosis, | 265800 |
DHODH | 111.8 | 1 | 0.99 | Miller syndrome, | 263750 |
DISP1 | 222.4 | 0.99 | 0.99 | No OMIM phenotype | 263750 |
DISP1 | 222.4 | 0.99 | 0.99 | Craniofacial and neuro-developmental abnormalities (Roessler -2009 Hum Genet 125,393) | 263750 |
DISP1 | 222.4 | 0.99 | 0.99 | Diaphragmatic hernia, congenital (Kantarci -2010 Am J Med Genet A 152A,2493) | 263750 |
DISP1 | 222.4 | 0.99 | 0.99 | Tetralogy of Fallot (Silversides -2012 PLoS Genet 8 e | 1002843) |
DLX3 | 137.4 | 1 | 0.99 | Amelogenesis imperfecta, type IV, | 104510 |
DLX3 | 137.4 | 1 | 0.99 | Trichodontoosseous syndrome, | 190320 |
DLX4 | 146.1 | 0.99 | 0.99 | ?Orofacial cleft 15 | 616788 |
DSPP | 191 | 1 | 0.99 | Deafness, autosomal dominant 39 with dentinogenesis, | 605594 |
DSPP | 191 | 1 | 0.99 | Dentin dysplasia, type II, | 125420 |
DSPP | 191 | 1 | 0.99 | Dentinogenesis imperfecta, Shields type II, | 125490 |
DSPP | 191 | 1 | 0.99 | Dentinogenesis imperfecta, Shields type III, | 125500 |
EDA | 101 | 0.9 | 0.79 | Ectodermal dysplasia 1 hypohidrotic, X-linked, | 305100 |
EDA | 101 | 0.9 | 0.79 | Tooth agenesis, selective, X-linked 1 | 313500 |
EDAR | 145.9 | 0.99 | 0.98 | Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant, | 129490 |
EDAR | 145.9 | 0.99 | 0.98 | Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive, | 224900 |
EDAR | 145.9 | 0.99 | 0.98 | [Hair morphology 1 hair thickness], | 612630 |
EDARADD | 98.6 | 0.97 | 0.92 | Ectodermal dysplasia 11A, hypohidrotic/hair/tooth type, autosomal dominant, | 614940 |
EDARADD | 98.6 | 0.97 | 0.92 | Ectodermal dysplasia 11B, hypohidrotic/hair/tooth type, autosomal recessive, | 614941 |
EDN1 | 158.5 | 1 | 1 | Auriculocondylar syndrome 3 | 615706 |
EDN1 | 158.5 | 1 | 1 | Question mark ears, isolated, | 612798 |
EDN1 | 158.5 | 1 | 1 | {High density lipoprotein cholesterol level QTL 7} | 612798 |
EFNA4 | 118.4 | 1 | 1 | No OMIM phenotype | 612798 |
EFNA4 | 118.4 | 1 | 1 | Craniosynostosis 1 (Merrill et al, -2006 Hum Molec Genet 15) | 612798 |
EFNB1 | 142.4 | 1 | 0.99 | Craniofrontonasal dysplasia, | 304110 |
EFTUD2 | 125.4 | 0.99 | 0.99 | Mandibulofacial dysostosis, Guion-Almeida type, | 610536 |
EIF4A3 | 122.1 | 1 | 0.99 | Robin sequence with cleft mandible and limb abnormalities, | 268305 |
ENAM | 152.1 | 1 | 0.99 | Amelogenesis imperfecta, type IB, | 104500 |
ENAM | 152.1 | 1 | 0.99 | Amelogenesis imperfecta, type IC, | 204650 |
ERF | 125.9 | 0.99 | 0.97 | Craniosynostosis 4 | 600775 |
EYA1 | 160.1 | 0.99 | 0.98 | Anterior segment anomalies with or without cataract, | 113650 |
EYA1 | 160.1 | 0.99 | 0.98 | Branchiootic syndrome 1 | 602588 |
EYA1 | 160.1 | 0.99 | 0.98 | Branchiootorenal syndrome 1 with or without cataracts, | 113650 |
EYA1 | 160.1 | 0.99 | 0.98 | ?Otofaciocervical syndrome, | 166780 |
EZH2 | 153.3 | 0.99 | 0.98 | Weaver syndrome, | 277590 |
FAM83H | 83.2 | 0.95 | 0.89 | Amelogenesis imperfecta, type III, | 130900 |
FGD1 | 98.1 | 0.95 | 0.89 | Aarskog-Scott syndrome, | 305400 |
FGD1 | 98.1 | 0.95 | 0.89 | Mental retardation, X-linked syndromic 16 | 305400 |
FGF10 | 150.1 | 1 | 1 | Aplasia of lacrimal and salivary glands, | 180920 |
FGF10 | 150.1 | 1 | 1 | LADD syndrome, | 149730 |
FGF3 | 80.8 | 0.95 | 0.83 | Deafness, congenital with inner ear agenesis, microtia, and microdontia, | 610706 |
FGF8 | 127.4 | 0.85 | 0.79 | Hypogonadotropic hypogonadism 6 with or without anosmia, | 612702 |
FGFR1 | 161.5 | 0.99 | 0.97 | Encephalocraniocutaneous lipomatosis, | 613001 |
FGFR1 | 161.5 | 0.99 | 0.97 | Hartsfield syndrome, | 615465 |
FGFR1 | 161.5 | 0.99 | 0.97 | Hypogonadotropic hypogonadism 2 with or without anosmia, | 147950 |
FGFR1 | 161.5 | 0.99 | 0.97 | Jackson-Weiss syndrome, | 123150 |
FGFR1 | 161.5 | 0.99 | 0.97 | Osteoglophonic dysplasia, | 166250 |
FGFR1 | 161.5 | 0.99 | 0.97 | Pfeiffer syndrome, | 101600 |
FGFR1 | 161.5 | 0.99 | 0.97 | Trigonocephaly 1 | 190440 |
FGFR2 | 156.4 | 0.96 | 0.95 | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis, | 207410 |
FGFR2 | 156.4 | 0.96 | 0.95 | Apert syndrome, | 101200 |
FGFR2 | 156.4 | 0.96 | 0.95 | Beare-Stevenson cutis gyrata syndrome, | 123790 |
FGFR2 | 156.4 | 0.96 | 0.95 | Bent bone dysplasia syndrome, | 614592 |
FGFR2 | 156.4 | 0.96 | 0.95 | Craniofacial-skeletal-dermatologic dysplasia, | 101600 |
FGFR2 | 156.4 | 0.96 | 0.95 | Craniosynostosis, nonspecific | 101600 |
FGFR2 | 156.4 | 0.96 | 0.95 | Crouzon syndrome, | 123500 |
FGFR2 | 156.4 | 0.96 | 0.95 | Gastric cancer, somatic, | 613659 |
FGFR2 | 156.4 | 0.96 | 0.95 | Jackson-Weiss syndrome, | 123150 |
FGFR2 | 156.4 | 0.96 | 0.95 | LADD syndrome, | 149730 |
FGFR2 | 156.4 | 0.96 | 0.95 | Pfeiffer syndrome, | 101600 |
FGFR2 | 156.4 | 0.96 | 0.95 | Saethre-Chotzen syndrome, | 101400 |
FGFR2 | 156.4 | 0.96 | 0.95 | Scaphocephaly and Axenfeld-Rieger anomaly | 101400 |
FGFR2 | 156.4 | 0.96 | 0.95 | Scaphocephaly, maxillary retrusion, and mental retardation, | 609579 |
FGFR3 | 120.2 | 0.99 | 0.99 | Achondroplasia, | 100800 |
FGFR3 | 120.2 | 0.99 | 0.99 | Bladder cancer, somatic, | 109800 |
FGFR3 | 120.2 | 0.99 | 0.99 | CATSHL syndrome, | 610474 |
FGFR3 | 120.2 | 0.99 | 0.99 | Cervical cancer, somatic, | 603956 |
FGFR3 | 120.2 | 0.99 | 0.99 | Colorectal cancer, somatic, | 114500 |
FGFR3 | 120.2 | 0.99 | 0.99 | Crouzon syndrome with acanthosis nigricans, | 612247 |
FGFR3 | 120.2 | 0.99 | 0.99 | Hypochondroplasia, | 146000 |
FGFR3 | 120.2 | 0.99 | 0.99 | LADD syndrome, | 149730 |
FGFR3 | 120.2 | 0.99 | 0.99 | Muenke syndrome, | 602849 |
FGFR3 | 120.2 | 0.99 | 0.99 | Nevus, epidermal, somatic, | 162900 |
FGFR3 | 120.2 | 0.99 | 0.99 | SADDAN, | 616482 |
FGFR3 | 120.2 | 0.99 | 0.99 | Spermatocytic seminoma, somatic, | 273300 |
FGFR3 | 120.2 | 0.99 | 0.99 | Thanatophoric dysplasia, type I, | 187600 |
FGFR3 | 120.2 | 0.99 | 0.99 | Thanatophoric dysplasia, type II, | 187601 |
FOXC1 | 40.5 | 0.93 | 0.77 | Axenfeld-Rieger syndrome, type 3 | 602482 |
FOXC1 | 40.5 | 0.93 | 0.77 | Iridogoniodysgenesis, type 1 | 601631 |
FOXC1 | 40.5 | 0.93 | 0.77 | Iris hypoplasia and glaucoma, | 601631 |
FOXC1 | 40.5 | 0.93 | 0.77 | Rieger or Axenfeld anomalies, | 602482 |
FOXE1 | 31.4 | 0.76 | 0.6 | Bamforth-Lazarus syndrome, | 241850 |
FOXE1 | 31.4 | 0.76 | 0.6 | {Thyroid cancer, nonmedullary, 4}, | 616534 |
GDF3 | 139.5 | 1 | 1 | Klippel-Feil syndrome 3 autosomal dominant, | 613702 |
GDF3 | 139.5 | 1 | 1 | Microphthalmia with coloboma 6 | 613703 |
GDF3 | 139.5 | 1 | 1 | Microphthalmia, isolated 7 | 613704 |
GDF6 | 85.6 | 0.97 | 0.89 | Klippel-Feil syndrome 1 autosomal dominant, | 118100 |
GDF6 | 85.6 | 0.97 | 0.89 | Leber congenital amaurosis 17 | 615360 |
GDF6 | 85.6 | 0.97 | 0.89 | Microphthalmia with coloboma 6 digenic, | 613703 |
GDF6 | 85.6 | 0.97 | 0.89 | Microphthalmia, isolated 4 | 613094 |
GJA1 | 218.1 | 1 | 1 | Atrioventricular septal defect 3 | 600309 |
GJA1 | 218.1 | 1 | 1 | Craniometaphyseal dysplasia, autosomal recessive, | 218400 |
GJA1 | 218.1 | 1 | 1 | Erythrokeratodermia variabilis et progressiva, | 133200 |
GJA1 | 218.1 | 1 | 1 | Hypoplastic left heart syndrome 1 | 241550 |
GJA1 | 218.1 | 1 | 1 | Oculodentodigital dysplasia, | 164200 |
GJA1 | 218.1 | 1 | 1 | Oculodentodigital dysplasia, autosomal recessive, | 257850 |
GJA1 | 218.1 | 1 | 1 | Palmoplantar keratoderma with congenital alopecia, | 104100 |
GJA1 | 218.1 | 1 | 1 | Syndactyly, type III, | 186100 |
GJB6 | 226.9 | 1 | 1 | Deafness, autosomal dominant 3B, | 612643 |
GJB6 | 226.9 | 1 | 1 | Deafness, autosomal recessive 1B, | 612645 |
GJB6 | 226.9 | 1 | 1 | Deafness, digenic GJB2/GJB6, | 220290 |
GJB6 | 226.9 | 1 | 1 | Ectodermal dysplasia 2 Clouston type, | 129500 |
GLI2 | 139.5 | 0.98 | 0.96 | Culler-Jones syndrome, | 615849 |
GLI2 | 139.5 | 0.98 | 0.96 | Holoprosencephaly-9, | 610829 |
GLI3 | 170.9 | 1 | 0.99 | Greig cephalopolysyndactyly syndrome, | 175700 |
GLI3 | 170.9 | 1 | 0.99 | Pallister-Hall syndrome, | 146510 |
GLI3 | 170.9 | 1 | 0.99 | Polydactyly, postaxial, types A1 and B, | 174200 |
GLI3 | 170.9 | 1 | 0.99 | Polydactyly, preaxial, type IV, | 174700 |
GLI3 | 170.9 | 1 | 0.99 | {Hypothalamic hamartomas, somatic}, | 241800 |
GNAI3 | 126.8 | 0.99 | 0.94 | Auriculocondylar syndrome 1 | 602483 |
GRHL3 | 160 | 1 | 1 | Van der Woude syndrome 2 | 606713 |
HOXA2 | 90.9 | 0.99 | 0.95 | ?Microtia with or without hearing impairment (AD), | 612290 |
HOXA2 | 90.9 | 0.99 | 0.95 | ?Microtia, hearing impairment, and cleft palate (AR), | 612290 |
IFT122 | 164.4 | 1 | 0.99 | Cranioectodermal dysplasia 1 | 218330 |
IFT43 | 130.6 | 1 | 1 | Cranioectodermal dysplasia 3 | 614099 |
IKBKG | 56.2 | 0.84 | 0.7 | Ectodermal dysplasia, hypohidrotic, with immune deficiency, | 300291 |
IKBKG | 56.2 | 0.84 | 0.7 | Ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency, | 300301 |
IKBKG | 56.2 | 0.84 | 0.7 | Immunodeficiency 33 | 300636 |
IKBKG | 56.2 | 0.84 | 0.7 | Immunodeficiency, isolated, | 300584 |
IKBKG | 56.2 | 0.84 | 0.7 | Incontinentia pigmenti, | 308300 |
IKBKG | 56.2 | 0.84 | 0.7 | Invasive pneumococcal disease, recurrent isolated, 2 | 300640 |
IL11RA | 152.1 | 1 | 0.99 | Craniosynostosis and dental anomalies, | 614188 |
IRF6 | 136 | 0.99 | 0.97 | Popliteal pterygium syndrome 1 | 119500 |
IRF6 | 136 | 0.99 | 0.97 | van der Woude syndrome, | 119300 |
IRF6 | 136 | 0.99 | 0.97 | {Orofacial cleft 6}, | 608864 |
KAT6B | 202.7 | 0.99 | 0.98 | Genitopatellar syndrome, | 606170 |
KAT6B | 202.7 | 0.99 | 0.98 | SBBYSS syndrome, | 603736 |
KDM1A | 154.5 | 0.98 | 0.96 | Cleft palate, psychomotor retardation, and distinctive facial features, | 616728 |
KDM6A | 127.5 | 0.93 | 0.86 | Kabuki syndrome 2 | 300867 |
KLK4 | 210.9 | 0.99 | 0.98 | Amelogenesis imperfecta, type IIA1, | 204700 |
KMT2D | 162.1 | 0.99 | 0.99 | Kabuki syndrome 1 | 147920 |
KREMEN1 | 164.9 | 0.96 | 0.93 | No OMIM phenotype | 147920 |
LRP2 | 199.9 | 1 | 0.99 | Donnai-Barrow syndrome, | 222448 |
LRP6 | 186.6 | 1 | 0.99 | Tooth agenesis, selective, 7 | 616724 |
LRP6 | 186.6 | 1 | 0.99 | {Coronary artery disease, autosomal dominant, 2}, | 610947 |
LTBP3 | 126.4 | 0.98 | 0.96 | Dental anomalies and short stature, | 601216 |
MASP1 | 161.2 | 1 | 0.99 | 3MC syndrome 1 | 257920 |
MED12 | 116.5 | 0.98 | 0.95 | Lujan-Fryns syndrome, | 309520 |
MED12 | 116.5 | 0.98 | 0.95 | Ohdo syndrome, X-linked, | 300895 |
MED12 | 116.5 | 0.98 | 0.95 | Opitz-Kaveggia syndrome, | 305450 |
MEGF8 | 134 | 0.99 | 0.98 | Carpenter syndrome 2 | 614976 |
MEOX1 | 105.4 | 0.98 | 0.94 | Klippel-Feil syndrome 2 | 214300 |
MID1 | 196.6 | 0.99 | 0.98 | Opitz GBBB syndrome, type I, | 300000 |
MITF | 163 | 0.99 | 0.99 | Tietz albinism-deafness syndrome, | 103500 |
MITF | 163 | 0.99 | 0.99 | Waardenburg syndrome, type 2A, | 193510 |
MITF | 163 | 0.99 | 0.99 | Waardenburg syndrome/ocular albinism, digenic, | 103470 |
MITF | 163 | 0.99 | 0.99 | {Melanoma, cutaneous malignant, susceptibility to, 8}, | 614456 |
MMP20 | 117.5 | 0.99 | 0.99 | Amelogenesis imperfecta, type IIA2, | 612529 |
MSX1 | 88.1 | 0.97 | 0.91 | Ectodermal dysplasia 3 Witkop type, | 189500 |
MSX1 | 88.1 | 0.97 | 0.91 | Orofacial cleft 5 | 608874 |
MSX1 | 88.1 | 0.97 | 0.91 | Tooth agenesis, selective, 1 with or without orofacial cleft, | 106600 |
MSX2 | 105.4 | 0.99 | 0.94 | Craniosynostosis, type 2 | 604757 |
MSX2 | 105.4 | 0.99 | 0.94 | Parietal foramina 1 | 168500 |
MSX2 | 105.4 | 0.99 | 0.94 | Parietal foramina with cleidocranial dysplasia, | 168550 |
NAA10 | 111 | 0.99 | 0.96 | Ogden syndrome, | 300855 |
NAA10 | 111 | 0.99 | 0.96 | ?Microphthalmia, syndromic 1 | 309800 |
NFKBIA | 117.7 | 0.98 | 0.94 | Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency, | 612132 |
NIPBL | 129.3 | 0.96 | 0.94 | Cornelia de Lange syndrome 1 | 122470 |
NOG | 195.2 | 1 | 0.99 | Brachydactyly, type B2, | 611377 |
NOG | 195.2 | 1 | 0.99 | Multiple synostoses syndrome 1 | 186500 |
NOG | 195.2 | 1 | 0.99 | Stapes ankylosis with broad thumb and toes, | 184460 |
NOG | 195.2 | 1 | 0.99 | Symphalangism, proximal, 1A, | 185800 |
NOG | 195.2 | 1 | 0.99 | Tarsal-carpal coalition syndrome, | 186570 |
NSD1 | 172.3 | 1 | 0.99 | Beckwith-Wiedemann syndrome, | 130650 |
NSD1 | 172.3 | 1 | 0.99 | Leukemia, acute myeloid, | 601626 |
NSD1 | 172.3 | 1 | 0.99 | Sotos syndrome 1 | 117550 |
OFD1 | 56.1 | 0.84 | 0.71 | Joubert syndrome 10 | 300804 |
OFD1 | 56.1 | 0.84 | 0.71 | Orofaciodigital syndrome I, | 311200 |
OFD1 | 56.1 | 0.84 | 0.71 | Simpson-Golabi-Behmel syndrome, type 2 | 300209 |
OFD1 | 56.1 | 0.84 | 0.71 | ?Retinitis pigmentosa 23 | 300424 |
OTX2 | 149.8 | 1 | 0.99 | Microphthalmia, syndromic 5 | 610125 |
OTX2 | 149.8 | 1 | 0.99 | Pituitary hormone deficiency, combined, 6 | 613986 |
OTX2 | 149.8 | 1 | 0.99 | Retinal dystrophy, early-onset, with or without pituitary dysfunction, | 610125 |
PAX3 | 129.7 | 0.99 | 0.99 | Craniofacial-deafness-hand syndrome, | 122880 |
PAX3 | 129.7 | 0.99 | 0.99 | Rhabdomyosarcoma 2 alveolar, | 268220 |
PAX3 | 129.7 | 0.99 | 0.99 | Waardenburg syndrome, type 1 | 193500 |
PAX3 | 129.7 | 0.99 | 0.99 | Waardenburg syndrome, type 3 | 148820 |
PAX6 | 156.1 | 1 | 0.99 | Aniridia, | 106210 |
PAX6 | 156.1 | 1 | 0.99 | Cataract with late-onset corneal dystrophy, | 106210 |
PAX6 | 156.1 | 1 | 0.99 | Coloboma of optic nerve, | 120430 |
PAX6 | 156.1 | 1 | 0.99 | Coloboma, ocular, | 120200 |
PAX6 | 156.1 | 1 | 0.99 | Foveal hypoplasia 1 | 136520 |
PAX6 | 156.1 | 1 | 0.99 | Keratitis, | 148190 |
PAX6 | 156.1 | 1 | 0.99 | Optic nerve hypoplasia, | 165550 |
PAX6 | 156.1 | 1 | 0.99 | Peters anomaly, | 604229 |
PAX6 | 156.1 | 1 | 0.99 | ?Morning glory disc anomaly, | 120430 |
PAX7 | 115.6 | 0.99 | 0.99 | Rhabdomyosarcoma 2 alveolar, | 268220 |
PAX9 | 254.3 | 0.99 | 0.98 | Tooth agenesis, selective, 3 | 604625 |
PITX2 | 155.7 | 0.99 | 0.97 | Axenfeld-Rieger syndrome, type 1 | 180500 |
PITX2 | 155.7 | 0.99 | 0.97 | Iridogoniodysgenesis, type 2 | 137600 |
PITX2 | 155.7 | 0.99 | 0.97 | Peters anomaly, | 604229 |
PITX2 | 155.7 | 0.99 | 0.97 | Ring dermoid of cornea, | 180550 |
PLCB4 | 147.9 | 0.99 | 0.95 | Auriculocondylar syndrome 2 | 614669 |
POLR1C | 124.8 | 0.99 | 0.95 | Leukodystrophy, hypomyelinating, 11 | 616494 |
POLR1C | 124.8 | 0.99 | 0.95 | Treacher Collins syndrome 3 | 248390 |
POLR1D | 196.1 | 1 | 1 | Treacher Collins syndrome 2 | 613717 |
PORCN | 145.4 | 1 | 0.99 | Focal dermal hypoplasia, | 305600 |
PTCH1 | 138.6 | 0.98 | 0.96 | Basal cell carcinoma, somatic, | 605462 |
PTCH1 | 138.6 | 0.98 | 0.96 | Basal cell nevus syndrome, | 109400 |
PTCH1 | 138.6 | 0.98 | 0.96 | Holoprosencephaly-7, | 610828 |
PTH1R | 115.5 | 0.99 | 0.99 | Chondrodysplasia, Blomstrand type, | 215045 |
PTH1R | 115.5 | 0.99 | 0.99 | Eiken syndrome, | 600002 |
PTH1R | 115.5 | 0.99 | 0.99 | Failure of tooth eruption, primary, | 125350 |
PTH1R | 115.5 | 0.99 | 0.99 | Metaphyseal chondrodysplasia, Murk Jansen type, | 156400 |
PVRL1 | 163 | 1 | 0.99 | Cleft lip/palate-ectodermal dysplasia syndrome, | 225060 |
PVRL1 | 163 | 1 | 0.99 | Orofacial cleft 7 | 225060 |
RAB23 | 121.6 | 0.99 | 0.98 | Carpenter syndrome, | 201000 |
RAD21 | 97.7 | 0.99 | 0.96 | Cornelia de Lange syndrome 4 | 614701 |
RECQL4 | 150 | 0.98 | 0.97 | Baller-Gerold syndrome, | 218600 |
RECQL4 | 150 | 0.98 | 0.97 | RAPADILINO syndrome, | 266280 |
RECQL4 | 150 | 0.98 | 0.97 | Rothmund-Thomson syndrome, | 268400 |
RUNX2 | 106.2 | 0.74 | 0.74 | Cleidocranial dysplasia, | 119600 |
RUNX2 | 106.2 | 0.74 | 0.74 | Cleidocranial dysplasia, forme fruste, dental anomalies only, | 119600 |
RUNX2 | 106.2 | 0.74 | 0.74 | Cleidocranial dysplasia, forme fruste, with brachydactyly, | 119600 |
RUNX2 | 106.2 | 0.74 | 0.74 | Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly, | 156510 |
SALL1 | 147.9 | 0.99 | 0.98 | Townes-Brocks branchiootorenal-like syndrome, | 107480 |
SALL1 | 147.9 | 0.99 | 0.98 | Townes-Brocks syndrome, | 107480 |
SALL4 | 154.6 | 0.98 | 0.96 | Duane-radial ray syndrome, | 607323 |
SALL4 | 154.6 | 0.98 | 0.96 | IVIC syndrome, | 147750 |
SATB2 | 120.1 | 0.98 | 0.93 | Glass syndrome, | 612313 |
SEMA3E | 167.9 | 0.99 | 0.98 | ?CHARGE syndrome, | 214800 |
SF3B4 | 91.8 | 0.99 | 0.95 | Acrofacial dysostosis 1 Nager type, | 154400 |
SH3BP2 | 120.1 | 0.91 | 0.9 | Cherubism, | 118400 |
SHH | 110.4 | 0.98 | 0.94 | Holoprosencephaly-3, | 142945 |
SHH | 110.4 | 0.98 | 0.94 | Microphthalmia with coloboma 5 | 611638 |
SHH | 110.4 | 0.98 | 0.94 | Schizencephaly, | 269160 |
SHH | 110.4 | 0.98 | 0.94 | Single median maxillary central incisor, | 147250 |
SIX1 | 121.1 | 0.99 | 0.96 | Brachiootic syndrome 3 | 608389 |
SIX1 | 121.1 | 0.99 | 0.96 | Deafness, autosomal dominant 23 | 605192 |
SIX3 | 157.3 | 0.99 | 0.96 | Holoprosencephaly-2, | 157170 |
SIX3 | 157.3 | 0.99 | 0.96 | Schizencephaly, | 269160 |
SKI | 90.1 | 0.98 | 0.95 | Shprintzen-Goldberg syndrome, | 182212 |
SMC1A | 120 | 1 | 0.99 | Cornelia de Lange syndrome 2,30059 | 182212 |
SMC3 | 95.1 | 0.93 | 0.86 | Cornelia de Lange syndrome 3 | 610759 |
SMOC2 | 119.4 | 0.97 | 0.92 | Dentin dysplasia, type I, with microdontia and misshapen teeth, | 125400 |
SNAI2 | 151.2 | 1 | 0.99 | Piebaldism, | 172800 |
SNAI2 | 151.2 | 1 | 0.99 | Waardenburg syndrome, type 2D, | 608890 |
SOX10 | 80.4 | 0.97 | 0.93 | PCWH syndrome, | 609136 |
SOX10 | 80.4 | 0.97 | 0.93 | Waardenburg syndrome, type 2E, with or without neurologic involvement, | 611584 |
SOX10 | 80.4 | 0.97 | 0.93 | Waardenburg syndrome, type 4C, | 613266 |
SOX6 | 123.1 | 0.99 | 0.97 | No OMIM phenotype | 613266 |
SOX6 | 123.1 | 0.99 | 0.97 | Developmental delay and spinal syrinx (Scott -2014 J Child Neurol 29 NP164) | 613266 |
SOX6 | 123.1 | 0.99 | 0.97 | Dystonia, dopa-responsive (Ebrahimi-Fakhari -2015 Pediatr Neurol 52,115) | 613266 |
SOX6 | 123.1 | 0.99 | 0.97 | ?Craniosynostosis (Tagariello -2006 J Med Genet 43,534) | 613266 |
SPECC1L | 172.6 | 1 | 1 | Opitz GBBB syndrome, type II, | 145410 |
SPECC1L | 172.6 | 1 | 1 | ?Facial clefting, oblique, 1 | 600251 |
SUMO1 | 17.9 | 0.56 | 0.36 | Orofacial cleft 10 | 613705 |
TBX22 | 138.3 | 0.99 | 0.96 | Cleft palate with ankyloglossia, | 303400 |
TBX22 | 138.3 | 0.99 | 0.96 | ?Abruzzo-Erickson syndrome, | 302905 |
TCF12 | 168 | 1 | 0.99 | Craniosynostosis 3 | 615314 |
TCOF1 | 102.6 | 0.99 | 0.97 | Treacher Collins syndrome 1 | 154500 |
TFAP2A | 138 | 1 | 0.99 | Branchiooculofacial syndrome, | 113620 |
TGFBR1 | 213.8 | 0.95 | 0.93 | Loeys-Dietz syndrome 1 | 609192 |
TGFBR1 | 213.8 | 0.95 | 0.93 | {Multiple self-healing squamous epithelioma, susceptibility to}, | 132800 |
TGFBR2 | 215.3 | 1 | 1 | Colorectal cancer, hereditary nonpolyposis, type 6 | 614331 |
TGFBR2 | 215.3 | 1 | 1 | Esophageal cancer, somatic, | 133239 |
TGFBR2 | 215.3 | 1 | 1 | Loeys-Dietz syndrome 2 | 610168 |
TGIF1 | 151.6 | 0.99 | 0.99 | Holoprosencephaly-4, | 142946 |
TP63 | 217.6 | 1 | 1 | ADULT syndrome, | 103285 |
TP63 | 217.6 | 1 | 1 | Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 | 604292 |
TP63 | 217.6 | 1 | 1 | Hay-Wells syndrome, | 106260 |
TP63 | 217.6 | 1 | 1 | Limb-mammary syndrome, | 603543 |
TP63 | 217.6 | 1 | 1 | Orofacial cleft 8 | 129400 |
TP63 | 217.6 | 1 | 1 | Rapp-Hodgkin syndrome, | 129400 |
TP63 | 217.6 | 1 | 1 | Split-hand/foot malformation 4 | 605289 |
TRAF6 | 105.9 | 0.96 | 0.88 | No OMIM phenotype | 605289 |
TRAF6 | 105.9 | 0.96 | 0.88 | Ectodermal dysplasia, hypohidrotic (Wisniewski -2012 Br J Dermatol 166,1353) | 605289 |
TSHZ1 | 173.3 | 0.98 | 0.98 | Aural atresia, congenital, | 607842 |
TWIST1 | 143 | 0.95 | 0.86 | Craniosynostosis, type 1 | 123100 |
TWIST1 | 143 | 0.95 | 0.86 | Robinow-Sorauf syndrome, | 180750 |
TWIST1 | 143 | 0.95 | 0.86 | Saethre-Chotzen syndrome with eyelid anomalies, | 101400 |
TWIST1 | 143 | 0.95 | 0.86 | Saethre-Chotzen syndrome, | 101400 |
UBB | 71.7 | 1 | 0.99 | Cleft palate, isolated, | 119540 |
VAX1 | 61.3 | 0.89 | 0.79 | ?Microphthalmia, syndromic 11 | 614402 |
WDR19 | 153.5 | 0.99 | 0.97 | Nephronophthisis 13 | 614377 |
WDR19 | 153.5 | 0.99 | 0.97 | Senior-Loken syndrome 8 | 616307 |
WDR19 | 153.5 | 0.99 | 0.97 | ?Cranioectodermal dysplasia 4 | 614378 |
WDR19 | 153.5 | 0.99 | 0.97 | ?Short-rib thoracic dysplasia 5 with or without polydactyly, | 614376 |
WDR35 | 167.2 | 0.98 | 0.96 | Cranioectodermal dysplasia 2 | 613610 |
WDR35 | 167.2 | 0.98 | 0.96 | Short-rib thoracic dysplasia 7 with or without polydactyly, | 614091 |
WDR72 | 161.7 | 0.99 | 0.97 | Amelogenesis imperfecta, type IIA3, | 613211 |
WNT10A | 114.7 | 0.99 | 0.98 | Odontoonychodermal dysplasia, | 257980 |
WNT10A | 114.7 | 0.99 | 0.98 | Schopf-Schulz-Passarge syndrome, | 224750 |
WNT10A | 114.7 | 0.99 | 0.98 | Tooth agenesis, selective, 4 | 150400 |
ZEB2 | 181.5 | 1 | 0.99 | Mowat-Wilson syndrome, | 235730 |
ZIC2 | 111.1 | 0.89 | 0.79 | Holoprosencephaly-5, | 609637 |